Kyoko Hori is a popular, smart high school girl, while Izumi Miyamura is a gloomy, quiet boy. Outside of school, Hori is a hardworking homebody, and Miyamura is a heavily pierced, tattooed gentle soul. When they accidentally discover each other's hidden personas, they form a deep bond.

Dr. Kenzo Tenma, a brilliant Japanese neurosurgeon working in Germany, chooses to save the life of a young boy over a wealthy politician. Years later, he discovers that the boy grew up to become a charismatic, calculating serial killer.

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The incredible orchestral score by Hiroyuki Sawano elevates the intense, heart-wrenching plot twists.