Run the downloaded installer application. If deploying on enterprise networks with limited privileges, launch the command prompt as an administrator and execute the silent setup string: msiexec.exe /p ArcGISPro_295_180234.msp /qb Use code with caution.

You must have ArcGIS Pro 2.9 already installed before applying this patch. Key Features of Patch 5

ArcGIS Pro 2.9 Patch 5 2.9.5 link